A Study On Low K13 Mutation Profile - 971 Words

Low K13 mutation profile, after introduction of Artemether-Lumefantrine, in Msambweni coastal region, Kenya. Reuben Mwikiio kinyanzwii 1 3*, Francis .T. Kimani 3, Laura Wangai 2 Eric Lelo 3 Edwin Too 3, Denis Mwaniki.1 1 Institute of Tropical Medicine and Infectious Diseases (ITROMID), Nairobi, Kenya, 2 School of Health Sciences, Kirinyaga University College (Constituent College of JKUAT), Kerugoya, Kenya, 3 Kenya Medical Research Institute, Centre for Biotechnology Research and Development (KEMRI, CBRD), Nairobi, Kenya. Corresponding Author: Reuben Mwikiio Kinyanzwii* reubenkinyanzwii@gmail.com Abstract Introduction: Worldwide emergence and spread of antimalarial resistance has led to use of molecular markers in monitoring of resistant plasmodium parasite. Single nucleotide polymorphisms in the K13 propellor domain have been recently associated with artemisinin resistance. This study aims at profiling K13 molecular markers related to reduced susceptibility to Artemether-Lumefantrine in parasite isolates from Msambweni coastal region, Kenya. Methods: Chelex method was used for extracting DNA from Plasmodium falciparum positive dried blood spots on filter paper samples. Polymerase chain reaction and sequencing technique was used to detect single nucleotide polymorphism in K13 propeller gene. MEGA 6 was used to identify specific SNP combinations using wild-type reference sequence (XM_001350122). Results: A total 150 samples were collected from malaria infected patients in

East Of Eden By John Steinbeck - 2495 Words

John Steinbeck’s novel, â€Å"East of Eden†, discloses the answer of right and wrong, good versus evil and overcoming sin with a simple Hebrew word â€Å"Timshel†, meaning thou mayest, allowing us the freedom to make our individual decisions or choose our path in life; it’s actually God’s perfect gift to everyone. In the beginning, God grants us free will so that we have the ability to love and accept him or not. However, had God not chosen to grant us free will, we would not be human as we know it today, for the original sin would never have occurred. Likewise, people’s inability to experience emotions of any kind, whatsoever, would turn us into mere mundane robots, forced to listen and answer to an authoritarian God. Lee plays an instrumental part in â€Å"East of Eden†, by not only bringing into focus â€Å"Timshel† and its meaning to the Trask family but through his strength and character as a whole, for without Lee â€Å"E ast of Eden† and the concept of â€Å"Timshel† is non-existent. Lee’s character in â€Å"East of Eden† commences when Adam and Cathy move to California and Adam purchases land or his â€Å"Garden in Eden† as Adam refers to it. Lee described in the beginning as a Chinaman sporting a queue and only speaking in pidgin. However, the more one discovers about Lee in the book; the more one finds this is not the case at all. Lee is Chinese-American, who is extremely knowledgeable, well-spoken, well-read, insightful and thought provoking. He was born in a railroad camp, where his mother disguisedShow MoreRelatedEast of Eden by John Steinbeck624 Words   |  2 Pagesworld: one that is able to change and others that refuses to change. In the novel, East of Eden by John Steinbeck, Steinbeck mainly focuses on female character that can be illustrated as either a person who is able to fit in to changes as a wife and a mother, or who simply just deviates from home and/or family life. Although Steinbeck characterizes Liza as an example of a completely devoted wife and a mother, Steinbeck evokes the idea that a domestic woman is not really true of Liza: but is also independentRead MoreEast Of Eden By John Steinbeck2066 Words   |  9 Pagesauthor always has a motive for writing a story and a point they are trying to get across. John Steinbeck has written some very influential novels in his life. These books are read in high schools, as well as in people s free time to try and expand their minds and change their perspectives on life. Steinbeck has a very descriptive writing style that helps make his books classic novels worth reading. Steinbeck is a writer that does a great job of not just blatantly telling the reader what he wantsRead MoreFree Will in East of Eden by John Steinbeck1002 Words   |  5 Pagessignificant role in East of Eden. It shows that anyone can desire to surmount vile in their hearts and create morality within them self. In the novel, Steinbeck portrays the significance of timshel through the introduction of free will, the internal conflict of Caleb, and the blessing of Adam. Steinbeck portrays the significance of timshel through the introduction of free will, which plays an important role in the theme of Cain and Abel and provides the interpretation of Steinbeck. Timshel is broughtRead MoreJohn Steinbeck s East Of Eden1087 Words   |  5 Pagesto leave an inspirational impression on his sons, John Steinbeck portrays experiences he acquired from his childhood in the novel East of Eden through the characters’ conflicts and actions to encourage them to write their own story not dictated by their roots. Steinbeck admits in Journal of a Novel: The East of Eden Letters that he â€Å"hopes his two young sons will find meaning in life when they grow and acquire the experiences to understand.† Steinbeck s failure to feel accepted, accept his father sRead MoreJohn Steinbeck s East Of Eden1742 Words   |  7 PagesI. SUBJECT John Steinbeck’s East of Eden centers on the Trask and Hamilton families in the year 1902 in the Salinas Valley, California. After growing up in Connecticut alongside his brother Charles under the harsh parenting and rejection of his father, Adam Trask seeks to find happiness and peace. He vows to be a better man than his father and feels the rolling valleys of California calling him. One night, Cathy Ames crawls onto the doorstep of Adam and Charles’ home after her boyfriend attemptedRead MoreJohn Steinbeck s East Of Eden893 Words   |  4 PagesA central question raised by John Steinbeck’s East of Eden is whether it is possible to triumph over evil, answered by the discussion of free will and inherited sin. The idea of â€Å"timshel† is canvassed through the struggles of Caleb â€Å"Cal† Trask. The concept of inherited sin is illustrated through the actions of Cyrus Trask, Charles Trask, and Cathy/Kate Trask. Although Cal is seemingly â€Å"born† into evil, he struggles against what he sees as his inherited evil from his mother and is eventually ableRead MoreJohn Steinbeck s East Of Eden1342 Words   |  6 Pagesto fall back. Might it not be that in the dark pools of some men the evil grows strong enough to wriggle over the fence and swim free? Would not such a man be our monster, and are we related to him in our hidden water?† (Steinbeck 133). The novel, East of Eden, by John Steinbeck, interprets that every human being since Cain and Abel has struggled with the choice between good and evil. He dramatizes the conflict between wickedness and purity within the Trask family and the main characters of the novelRead MoreJohn Steinbeck s East Of Eden1279 Words   |  6 PagesHistory, is the story among which all literary works are linked to, and this statement is true more than any other in John Steinbeck’s East of Eden. Whether one believes that all stories in the Bible have actually happened or not, at least some concepts of them did. How would a writer arrive at the ideas of two brothers and jealousy of love, without having seen it or felt it before? Yet again, how would these ideas survive for so long, unless many people felt them as well and connected to them. TheRead MoreJohn Steinbeck s East Of Eden1072 Words   |  5 Pages once the illusion is destroyed, it also destroys him. Similarly, John Steinbeck explores the double-edged sword of deception, wielded by both children and adults, in his novel East of Eden. Just as the masks that society wears, multiple characters throughout the story at first originally incapable of committing a sin as great as deceit due to their innocent introductions. Despite this initial virtuosity, Steinbeck’s East of Eden evinces humanity’s contrasting and inherent dependence upon selfishRead MoreJohn Steinbeck s East Of Eden1763 Words   |  8 PagesEast of Eden, written by John Steinbeck, is a profound, complicated retelling of the biblical story of Cain and Abel, focused around the overall struggle between good and evil . John Steinbeck wrote this for his own sons, John and Tom, to show them not only the history of their family in the Hamiltons, but also the concept of sibling rivalry emerging from the competition over paternal love and acceptance (Shillinglaw). This was first evident in Adam and Charles Trask, and then in Adam’s sons, Ar on

Tattoos Free Essays

Tattoos BY rhtanne0529 Many people Judge the outward expression of others’ creativity and beauty. Though opinions of this art form have become more accepting, it is still considered taboo. Tattoos should not determine people’s views or thoughts on those who have them. We will write a custom essay sample on Tattoos or any similar topic only for you Order Now At one time, society thought tattoos were only for those in biker gangs or the military. Only the outcasts of society were known to partake in the taboo tradition. Actually, anyone, from a college professor to a soccer mom, can have a tattoo. The presence or absence of body art does not define the person. I have four tattoos that I decided to get for various reasons and at different times in my life. Each has a special meaning and allows me to have an outward representation of emotions I sometimes cannot voice. My tattoos are an expression of my personality, and no one should Judge me for them. I have faced adversity, even from family members, due to my tattoos and piercings. I did not take getting a tattoo lightly. I did not walk into a random shop and point out a drawing on the wall to be inked on my skin. I talked to my parents, riends, pastor and tattoo artists before getting tattooed. I wanted my decision to be well informed so I would never regret it. Though I know I did nothing wrong, I still face people who Judge me. Dr. Martin Luther King Jr. said he hoped his children would not be Judged by the color of their skin but the content of the character. Though his â€Å"l Have a Dream† speech did not refer to tattoos, it advocated equality. It should not matter if someone is white, black, green or tattooed, everyone should be treated the same. People should be Judged by their character, not their appearance. It is who a person is on the inside that matters. As Christians, we are commanded not to Judge anyone, whether it is for their actions or their appearance. God will be the one to Judge me. My Father created me beautifully and loves all of me, including my tattoos. Tattoos, honestly, are Just as much of a way to show style and artistic value as the types of clothing worn; except, they are permanent. Until someone gets to know a person with tattoos, they should not believe any stereotype about the tattooed. We are all humans and need to show love by not Judging others’ appearances. How to cite Tattoos, Papers